Large red blood cells may also be seen in certain diseases (such as feline leukemia virus infection), certain vitamin or mineral deficiencies, or may be a normal finding in some poodles. Large red blood cells may be seen in cases of anemia in the face of low red blood cells, bone marrow, which makes red blood cells, is triggered to prematurely release immature red blood cells (or reticulocytes, which are larger than the mature red blood cells typically released into the bloodstream in normal patients). Although healthy animals are typically normocytic, normally-sized red blood cells may also be observed in certain chronic illnesses (such as kidney failure or certain cancers). Normally-sized red blood cells are termed normocytic while red blood cells that are too large or too small are called macrocytic and microcytic, respectively. MCV: Mean Corpuscular Volume measures the average size of red blood cells.If your pet is dehydrated, the same volume of blood will have less water content, causing red blood cells to make up a higher proportion of that same blood volume, creating a higher HCT or PCV than if your pet was well hydrated. A high HCT or PCV can indicate excitement (as previously explained) or dehydration. Just like a low RBC count, a low HCT or PCV also indicates anemia. Due to potential errors in the machine, HCT is not as accurate as PCV, which is measured visually by your vet or laboratory technician. HCT is calculated by the laboratory machine that analyzes the test tubes containing a blood sample. A normal measurement in a dog is about 45%, while normal in a cat is around 35%.
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